Category Archives: Sugar

The faux-low carb mouse and a diatribe

The faux-low carb mouse

Hyperinsulinemia drives diet-induced obesity blah blah blah (Mehran et al., 2012)

The researchers generated a mouse with half as much insulin as normal mice.  Physiological insulin levels remain intact, but hyperinsulinemia is genetically inhibited.  For the sake of simplicity, we’ll call them “InsKO.”

When fed a high fat diet, normal mice become markedly hyperinsulinemic (pink line) whereas InsKO mice maintain relatively normal insulin levels (red line).  Blue lines are chow-fed mice; similar trend but less interesting.

divide and conquer

InsKO mice don’t get fat,

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The curious effects of calories in mice

What is the biological impact of a history of obesity and weight loss?  The metabolic trajectory of two calorically restricted skinny mice depends entirely upon whether or not they used to be fat.  The end of this story might be: ‘Tis better to have lost and re-gained than never to have lost at all; or it’s just an interesting new take on the body weight set point theory.

Caloric restriction chronically impairs metabolic programming in mice (Kirchner et al., 2012)

divide and conquer

Part 1.
Study 1. Calorie restricted lean mice: the effect of diet composition.

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The Laws of Energy Balance FTW!

Weight loss maintenance is not determined by calorie intake… or physical activity… but by The Laws of Energy Balance FTW!!!

Odd, the sensation I felt when reading this news release (gloating?).  As reported at a meeting of the Obesity Society, results from the Utah Obesity Study of gastric bypass patients 2 and 6 years after surgery.  By the 2 year mark, they lost over 100 pounds, or 36% of their starting weight (went from 296 to 189 pounds).  Energy expenditure declined from 2201 to 1736 kcal/day.  Food intake went from 2085 to 1638 kcal/day.  (Hint: it’s no coincidence that energy expenditure and food intake declined to the exact same degree.)  Physical activity and fitness levels increased.

By the 6 year mark, they still weighed 29% less than their starting weight.  N.B. that’s an amazing level of success, it’s virtually unheard of in diet intervention studies.  +1 for gastric bypass; -1 for nutrition.

Here’s what piqued my interest: during the gradual increase from 189 pounds to 210 pounds, which occurred between years 2 and 6 post-surgery, the most significant factor associated with weight regain was not calorie intake or physical activity… it was metabolic rate.  This represents another fail for “eat less move more,” and a win for the Laws of Energy Balance.

So what’s this got to do with The poor, misunderstood calorie?

what we know about metabolic rate:

1)      It’s invisible.

2)      Fructose vs. The Laws of Energy Balance (circa December, 2011): sugar-sweetened beverages can cause fat gain, not by providing excess calories, but by reducing metabolic rate.

3)      Holiday feasts, the freshman 15, and damage control (circa January 2012): overeating a high protein diet causes less fat gain than overeating anything else because it increases metabolic rate.

4)      Missing: 300 kilocalories (circa July 2012):  after losing weight, subjects assigned to the low carb diet maintained a higher metabolic rate than those on an isocaloric low fat diet.

“Eat less move more” is not the answer.  But eating less sugar, more protein, and fewer carbs might be.  Nutrition matters.

calories proper

Protein bar takedown, part III (or V)

No more pretense or cute backstory; I just like reviewing ingredient profiles of protein bars.  It’s a hobby of mine:
Candy in disguise, Op. 73 (circa April 2012)
Decepticon Promicor (soluble corn fiber), Op. 81 (June 2012)
Candy in disguise II, Op. 87 (July 2012)
Protein bar round-up, take II (September 2012)

See?

This is a review of Netrition’s “highest rated” bars.  Important notes about this category: these are not necessarily “new” protein bars, or even the bars everyone buy (“best sellers”).  They are the bars everyone who votes like the most.  They’re not the healthiest either… but some come close.   Continue reading

Corn. A riddle, wrapped in a mystery, inside an enigma.

Utterly.  Shocked.  is how I feel gazing upon the ingredients listed on one particular popular snack food.  And it isn’t one of those fancy gourmet all-natural whole food snacks, it is a classic that is probably in the kitchen of every child-wielding household.

Corn, corn oil, and salt.  And salt doesn’t even count, so it might just as well have said corn and corn oil, which could be summarized as “corn.”  Ladies and gentlemen, I present to you, the reigning champion of snack food sorcery, the red-headed stepchild (no offense) of international superpower PepsiCo… Fritos.  Using only corn, the wizards of Frito-Lay are turning this:into this:

and that’s without the use of trans fat, gluten, artificial additives, dairy, msg, onions, or soy.  They’re Kosher too.

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BPA

Though they won’t kill you [instantly], environmental and dietary xenoestrogens warrant a bit of attention, especially considering their theoretical mechanism of action is, among other things, augmenting insulin secretion.  This is of particular importance given the growing body of evidence of a causal role for insulin hypersecretion in the obesity epidemic (see Barbara Corkey’s 2011 Banting Lecture for an overview).

And this is the SECOND time this year BPA has made headlines.

BPA. Looks like some kind of medieval weapon or something.

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Soda vs. childhood obesity

What happens if you give skinny kids a can of fully sugared regular soda to drink every day for a year?

What happens if you take the soda away from overweight kids for a year?

The answer to these two questions should be a definitive user’s guide to the question: how bad is soda for my children?   And we got those answers this week.

 

A set of powerful studies were recently published, the likes of which I thought we’d never see.  It’s unethical to assign anyone to start smoking so we can properly study the effects of cigarettes; and before today, I would’ve thought it unethical to assign young children to start drinking fully sugared regular soda.  And not just one or two cans…  over 350.  For the 4 year olds the first study, by the end of the trial they had been on soda for almost a third of their life… during a critical period of development.  Ethics schmethics.  Hopefully this study will never be repeated.

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Why diets fail, Op. 106

Correction: diets don’t fail, dieters do.  And don’t take that the wrong way; adhering to a restrictive diet is one of the most difficult tasks for ANYone; thus, the obesity epidemic.  Some recent insights into diet-induced weight loss success, or lack thereof, have shed a new light on why some dieters adhere and others don’t.

In Insulin resistance, I discussed how insulin sensitivity may influence how well someone responds to a diet.  In brief, insulin resistant obese people do much better on low carb than low fat in a closely controlled clinical setting.  If you’re one of the lucky few insulin sensitive obese people, then simply reducing calories works.  Unfortunately, however, most obese are insulin resistant.

When it comes to devising a weight loss strategy, I’m willing to cut every corner and use every trick in the book to achieve success.  Data in this new analysis came from Chris Gardner’s notorious A to Z study, where patients were given diet books and told to have at it.  It was the weakest intervention in the history of diet studies, but it is exactly what everyone who wants to lose weight does.  And just like in Gardner’s study, most people fail.

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Insulin resistance

Why it is important and what you can do about it, Op. 105

 

This post was largely inspired by a recent manuscript by Chris Gardner.  He’s an outside-the-box thinker and if you haven’t heard of him, check out this YouTube video: The Battle of the Diets: Is Anyone Winning (At Losing?)

Part I.  

Type II diabetes is the clinical manifestation of insulin resistance.  It is preceded by obesity (except in the cases of MONW & NOD), and caused by poor nutrition.  Markers of insulin resistance are: 1) impaired fasting glucose; 2) impaired glucose tolerance; and 3) elevated HbA1c.  THIS is why it is important: in 2009, Barr and colleagues showed a linear relationship between all three of these risk factors and all-cause mortality in the AusDiab study.  All.  Cause.  Mortality.

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Protein bar round-up, take II.

The meaning of ingredients, just the facts.

My official statement:  protein bars are not superior to high protein foods like steak or eggs; they’re just incredibly convenient.  For exercisers, it is much easier to snack on a protein bar than a Tupperware bowl full of chicken (on your way TO the gym, that is).  They shouldn’t be relied upon for providing substantial nutrition because, well, they don’t.

That said, while perusing the various categories of protein bars at Bodybuilding.com, I found some big differences between the “best sellers,” “newest,” and “highest rated.”  So which should you buy: what everyone else is buying (best sellers)? the new kids on the block (newest)? or the favorite (highest rated)?

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