Category Archives: Uncategorized

Would you like your next meal to be your last… in a really long time??

The evolution continues beyond CIM debauchery – P:E & SPC

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For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Health “Biohacks”

Now that we’re being honest after the last article on light hygiene… there are things I know are very healthy but don’t do them because they don’t mesh with my lifestyle. Sometimes if I think they’re important, I make them mesh.

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Such is life.

These are some of the things I’m currently doing; an update of sorts.

Here are some more tips that may not have robust support from randomized clinical crossover trials, but my gut still seems to think they’re good. And low cost, not time-intensive, and importantly: relatively convenient.

Joint health

Oysters

Liver

For all the details, check out Patreon!

I have about a dozen more of these on deck but would like to hear from you. Requests? Feedback on these? Questions? Fire away! Leave a comment.

Part 2 next time!

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Most sleep drugs are absolute shit.

Check EEG studies on Ambien or any of the “Z-drugs.”

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They look identical to EEG studies on alcohol. When they work (not for everyone), they knock you out.

Not help you sleep. 

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Hey GLP-1 nerds, check out Nesfatin-1

(I’m including myself as a GLP-1 nerd)

[Patron link]

Check it out: Intraperitoneal administration of nesfatin?1 stimulates glucagon?like peptide?1 secretion in fasted mice (Tagawa et al., 2022

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

The All New “Uh-Oh CIM”

2 new mouse papers turning CIM upside down.

[Patron link]

Exhibit A. Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing (Meier et al., 2022)

PC1/3 is involved in the activation and function of certain proteins.

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

5x greater intake of seed oils. Place your bets!?

What do you think would happen if people were put on different diets under strictly controlled conditions, 16.5 vs 3.1 g seed oils/1000 kcal per day. Ad lib. 

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They’d start eating more and gain a ton of fat. Right? (See here for pictures of sample meals)

ABLC (animal-based low carb) vs. PBLF (plant-based low fat) (Hall et al., 2020)

SPIN DOCTORS STRIKE

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Rebranding GLP-1Ra & SGLT2i as “CIM”   O_o

Context: I’ve been a follower of and advocate for low carb diets for over 20 years. For many reasons. But this new gen of ketards is setting us back decades.

[Patreon link]

Rant warning.

First story is about the majestic GLP-1Ra (eg, semaglutide and tirzepatide). They act in the brain to suppress appetite very effectively. People report an inability to “clean their plates” like they used to. They eat less and lose fat. Clear victory for…..

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Seed oils.

You asked for it. I’ve written about linoleic acid many times going back about a decade, long before the “seed oil” fiasco. 

[Patreon link]

Eg, Molested fats, and inflammatory, trans, or linoleate.

Also, of relevance: Marijuana (see below)

Older theories were that it induced a pro-inflammatory environment (or anti-anti-inflammatory), but one of my main conclusions was where it was found. What foods?

As a percentage of what’s actually consumed providing the bulk linoleic acid, it’s snacks, donuts,,, empty calories. So was it the inflammatory or trans fat aspect that causes metabolic problems, or is it confounded? 

Adiposink revisited?

More fapping fat-trapping? Or the all new pull model of obesity?

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

This mouse-alcohol-energy balance study is breaking the internet.

EBM & CIM crowd came out in droves. Everyone’s an expert on energy balance now :/

[Patreon link]

More energy in, alcohol spilling everywhere, where’s the CO2, and more!

Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Canagliflozin, semaglutide, and tirzepatide OH MY

New players (from oldest to newest). All work. Now it comes down to a cost:benefit analysis.

[Patron link]

Not “costs” as in risks or side effects, and mechanisms aside, but literal price. In other words, people who haven’t reached their goal body fat with keto & resistance training and have other options available 🙂

Canagliflozin is a SGLT-2 inhibitor, so you pee out glucose (kinda mimics a low carb diet, minimally, but has beneficial metabolic effects).

Next up: semaglutide, tirzepatide, and a cost:benefit analysis.

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper