Category Archives: Dietary fat

Metabolic rate per se

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Admittedly, the effect of diet on metabolic rate is small (i.e. statistically non-significant in most cases), but its incredible consistency across space and time suggest it could be true.  And given the difficulty of maintaining a reduced body weight after dieting, it might even be important.  The following studies are examples of widely differing subject populations in various metabolic conditions; yet the effects of diet on metabolic rate exhibit a phenomenal degree of similarity.

disclaimer: I don’t know what’s more important – metabolic rate per se, the diet behind it, or the resulting hormonal adaptations.  All of the diets that are associated with a higher metabolic rate are also predicted to result in lower insulin levels and higher fat oxidation.  Thus, we are left with a triumvirate of diet, hormonal milieu, and energy expenditure… all of which are important for body composition and quality of life.

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[ketogenic] elite artistic gymnasts

Before you say anything, “elite artistic gymnasts” could probably beat you in a race running backwards.  (with you running forwards.)  They are elite athletes.  And given a sufficient keto-adaptation period, they perform better sans carbs.

Ketogenic diet does not affect strength performance in elite artistic gymnasts  (Paoli et al., 2012)

This study looked at body composition and various performance measures before and after 30 days of a very low carbohydrate ketogenic diet (“VLCKD,” < 25 grams of carbohydrate per day) or a normal diet (“WD,” > 250 grams of carbs per day).  25 grams of carbs is very very low, less than Atkins and Kwasniewski.  On the other hand, 41% protein is pretty high.

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Protein bar takedown, part III (or V)

No more pretense or cute backstory; I just like reviewing ingredient profiles of protein bars.  It’s a hobby of mine:
Candy in disguise, Op. 73 (circa April 2012)
Decepticon Promicor (soluble corn fiber), Op. 81 (June 2012)
Candy in disguise II, Op. 87 (July 2012)
Protein bar round-up, take II (September 2012)

See?

This is a review of Netrition’s “highest rated” bars.  Important notes about this category: these are not necessarily “new” protein bars, or even the bars everyone buy (“best sellers”).  They are the bars everyone who votes like the most.  They’re not the healthiest either… but some come close.   Continue reading

Corn. A riddle, wrapped in a mystery, inside an enigma.

Utterly.  Shocked.  is how I feel gazing upon the ingredients listed on one particular popular snack food.  And it isn’t one of those fancy gourmet all-natural whole food snacks, it is a classic that is probably in the kitchen of every child-wielding household.

Corn, corn oil, and salt.  And salt doesn’t even count, so it might just as well have said corn and corn oil, which could be summarized as “corn.”  Ladies and gentlemen, I present to you, the reigning champion of snack food sorcery, the red-headed stepchild (no offense) of international superpower PepsiCo… Fritos.  Using only corn, the wizards of Frito-Lay are turning this:into this:

and that’s without the use of trans fat, gluten, artificial additives, dairy, msg, onions, or soy.  They’re Kosher too.

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Why diets fail, Op. 106

Correction: diets don’t fail, dieters do.  And don’t take that the wrong way; adhering to a restrictive diet is one of the most difficult tasks for ANYone; thus, the obesity epidemic.  Some recent insights into diet-induced weight loss success, or lack thereof, have shed a new light on why some dieters adhere and others don’t.

In Insulin resistance, I discussed how insulin sensitivity may influence how well someone responds to a diet.  In brief, insulin resistant obese people do much better on low carb than low fat in a closely controlled clinical setting.  If you’re one of the lucky few insulin sensitive obese people, then simply reducing calories works.  Unfortunately, however, most obese are insulin resistant.

When it comes to devising a weight loss strategy, I’m willing to cut every corner and use every trick in the book to achieve success.  Data in this new analysis came from Chris Gardner’s notorious A to Z study, where patients were given diet books and told to have at it.  It was the weakest intervention in the history of diet studies, but it is exactly what everyone who wants to lose weight does.  And just like in Gardner’s study, most people fail.

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A historical argument against caloric equality

80 years later, a calorie still isn’t a calorie.

Exhibit A.

The treatment of obesity   (Lyon and Dunlop, 1932)

As early as 1932, Lyon and Dunlop recognized that the calories from as little as one slice of bread every day could result in pounds of fat mass gained every year.  For whatever reason, this doesn’t happen to lean people; so they decided to study the effect of different diets on obese subjects in a metabolic ward at the Royal Infirmary.

Their idea of a “diet:” If they could only see how much times have changed!  (this is a hotly debated topic.)

Lyon and Dunlop first tested weight loss vs. total calorie intake.  The diet was roughly 40% carbs, 24% protein, and 36% fat.  Not surprisingly, people fed 800 kcal/d lost more weight than those given 1,000 or 1,200 kcal/d (200 vs. 172 vs. 157 grams of body weight lost per day over the period of 7 – 10 days), confirming that the less you eat, the more weight you lose (duh).  A calorie is a calorie after all, right? …

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The easy diet diet II

Full disclosure.  IMHO, with regard to obesity and weight loss diets, low carb is a little bit better, most of the time.  It’s not such a huge difference that it’s ridiculously obvious, and in situations where low carb proper is too impractical, it might just be more important to focus on eliminating as many empty calories as possible.  Because as discussed in the Easy diet diet, Op. 72, you don’t have to go militant zero carb; simply “low carb seems to work pretty well.

In type 2 diabetes, randomization to advice to follow a low-carbohydrate diet transiently improves glycaemic control compared with advice to follow a low-fat diet producing a similar weight loss (Gulbrand et al., 2012)

[if you follow the advice, that is, at least to some degree] Continue reading

These nutters ate only meat for a year. Place your bets!

Who defines “moderation,” anyway?  An homage to pioneering nutrition research III, Op. 100.  Keep an open mind!  (and remember these words: “no clinical evidence of vitamin deficiency was noted.”)

MY LIFE WITH THE ESKIMO (Stefansson, 1913)

The effects on human beings of a twelve months’ exclusive meat diet (Lieb, 1929)

Prolonged meat diets with a study of kidney function and ketosis (McClellan and Du Bois, 1930)

Vilhjalmur Stefansson traveled with Eskimos in the Arctic for 9 years and lived almost exclusively on meat.  Then he and a fellow expeditioner (Andersen) decided to recapitulate this in a well-controlled, albeit warmer (New York), laboratory setting so they could document the metabolic insanity that ensued. At the time, the Eskimo diet was moderate protein, very high fat, yet they had no heart or kidney problems, were glucose tolerant, and exhibited no signs of ketoacidosis.  So the scientists said: “why not?”  (they were really hoping this apparent healthiness wasn’t due to the frigid Arctic temperatures.)

The studies describe the Central Plains’ Indians who subsisted almost entirely of buffalo meat, which they called the “staff of life,” and South American tribes which eat solely beef and water, then go on to say [sic]: “All of these races are noted for their endurance of exertion and hardships.”  They cite two tribes of Eskimos:  Greenlanders, who ate the typical diet (described above) and showed no signs of rickets or scurvey; and the Labradors, who had both diseases but ate more potatoes, flour, and cereals.  While traversing the Arctic, Andersen developed scurvy at a time when he was eating canned foods and very little meat; this was immediately cured by with raw meat :/

Food for thought: this diet is seriously deficient in vitamin C by today’s standards, but they exhibited NO symptoms.  Perhaps vitamin requirements vary based on the background diet?  Maybe our vitamin C requirement is increased by a Western diet (>50% carbs and lots of vegetable oils).  just sayin’

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Adipose, Horcrux of Metabolism

Part II.  The importance of the ability to un-store fat: implications for resistance exercise and muscle function in humans.

Adipose triglyceride lipase contributes to cancer-associated cachexia  (Das et al., 2011)

Mice and humans with certain types of cancer lose a lot of weight, a condition known as cachexia.  Besides causing a major decline in quality of life, this usually predicts mortality.  But tumor-burdened ATGLko mice exhibit none of this (closed bar = control; open bar = mice with tumors):

Unfortunately, much of this weight is type II muscle (left), while type I muscle is largely spared (right).  ATGLko mice are immune to muscle loss.

Type II muscle is white, burns sugar, and flexes fast and strong (that’s why I said “unfortunately,” above).  Type I muscle is red, burns fat, and flexes slow and weak.

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skinny is the new fat, Op. 95

I’ve been known to rave about the phenomenon of metabolically obese normal weight (MONW), or fat skinny people.  In brief, this population exhibits insulin resistance, metabolic syndrome, hypertension… all things usually associated with obesity… but they’re lean.   In fat skinny people, I wrote about two epidemiological studies on markedly different populations (Americans and Koreans); these two peoples have virtually nothing in common (culture, foods, genetics, etc.).  Despite these differences, there was a strong similarity in the macronutrients associated with metabolic dysregulation in otherwise lean individuals (aka fat skinny people): in the first study, high carb and low protein diets were the major culprits, with a smaller contribution of low fat.  In the second study, high carb and low fat were at fault (protein intake wasn’t analyzed).

A new study that is about to hit the presses didn’t intend to say anything about fat skinny people, but they weren’t counting on ME.

Body mass index, diabetes, hypertension, and short-term mortality: a population-based observational study, 2000-2006 (Jerant and Franks, 2012)

This study included over 50,000 people aged 18-90.  Between the years 2000 and 2005 about 3% died, which was statistically just enough to ask “why?”  In brief, they compared body weight, blood pressure, smoking, and diabetes with mortality risk.  

In each BMI category, the square is higher than the circle.  DM = diabetes (the squares).  Diabetes increases mortality risk independent of BMI.  Now just focusing on the squares; as you move from left to right, body weight is increasing but mortality risk in diabetics is decreasing.  A 150 pound diabetic has a higher mortality risk than a 200 pound diabetic, who has a higher mortality risk than a 250 pound diabetic.  Huh?

Perhaps the lean diabetics are fat skinny people, the elusive MONW?  If so, according to the research discussed HERE, their diet might have made them that way.  The lean diabetics (aka fat skinny people aka MONW aka NOD [non-obese diabetics]) eat less protein, more carbs, and less fat.  This might be a reach, but collectively (1 + 2 + 3) these data imply a poor diet might be worse than obesity for diabetics.

disclaimer: this is not true in most circumstances, i.e., skinny people can usually whatever they want.  There are skinny diabetics, but they are significantly rarer than obese diabetics.  In other words, most type II diabetics are obese, the lean ones just eat a crappier diet. You might be wondering: “how are they skinny if they eat so poorly?”  My guess is that they just haven’t eaten enough of it [yet]; it’s rare to stay lean on a “crappier diet.”

So is skinny the new fat?  Being lean with type II diabetes is an indicator of EMPTY CALORIES; it could be riskier for all-cause mortality than obesity in diabetics.

“Attention endocrinologists, diabetologists, and general practitioners: don’t assume diet is not a problem in your skinny diabetics because they are skinny.  Indeed, diet might be THE problem.”

And no, if you’re a skinny diabetic, this DOESN’T mean gaining weight will make you live longer.  it just doesn’t.

 

it just doesn’t.

calories proper