Cannabinoids and sleep

I was not looking forward to writing this, in part, due to my love-hate relationship with cannabinoids: on one hand, they show potential in many difficult-to-treat conditions; on the other hand, some psychiatric risks and this (CB receptor activation is diabetogenic).

[Patron link]

Further, don’t underestimate the complexity of cannabis plants and the endocannabinoid signaling system.

The cannabinoids (Babson et al., 2017):

-THC, the main psychoactive component of cannabis (also in drug form as Nabilone)

-CBD, a non-psychoactive component of cannabis

-Dronabinol, a highly purified synthetic (-)-trans-D9-THC. It’s actually 2-3x weaker than Nabilone (which is a further testament to the complexity of this system, imo).

Nabiximols (Sativex), a roughly 1:1 combination of THC & CBD.

To be clear, the main therapeutic use of cannabinoids is anti-emetic (prevents vomiting) & appetite-stimulation in some conditions (eg, cancer, HIV). The more interesting part, imo, is some of the human studies (discussed below) on people with difficult-to-treat conditions, who also sleep poorly, where any improvement in sleep quality inevitably improves their condition.

This article is specifically on sleep. I’ll do follow-ups on anxiety and maybe inflammation if you’re interested. Let me know!

For the rest of this and morehead over to Patreon! Join the community for up-to-date information about a variety of topics in the health & optimizing wellness space. Five bucks a month for access to this and all previous articles. It’s ad-free and you can cancel if it sucks 🙂

For personalized health consulting services:

Affiliate linksKetoLogic for keto-friendly shakes, creamers, snacks, etc. And get 15% off your ketone measuring supplies HERE.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. If you have no idea what I’m talking about, read this then this.

Join Binance and get some cryptoassets or download Honeyminer and get some Bitcoins for free

20% off some delish stocks and broths from Kettle and Fire HERE

If you want the benefits of  ‘shrooms but don’t like eating them, Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

Join with this link.

Start your OWN Patreon campaign!

calories proper