Palmitoylethanolamide. What now?

Palmitoylethanolamide (PEA, not to be confused with phenylethylamine).

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It does all the things in mice (alleviates pain, inflammation, anxiety, etc.), but now that it is widely available in supplement form, what is the evidence in humans?

It’s specific targets are largely unknown. PPARa? Endocannabinoid system? CB1? Others?

[doesn’t look like much, does it]

A few case studies and a clinic that pushes it HERE. Most start with 300 – 600 mg once or twice a day.

Histamine intolerance?

Remember when people used to joke about marijuana for eye health? Well, that might be partially true and argues for either: 1) a common endocannabinoid target of PEA and something in marijuana; or 2) cannabis has an extensive & complicated profile of bioactive compounds and PEA has nothing to do with the cannabinoid system (Costagliola et al., 2014 & Pescosolido et al., 2011).

More studies have been published on pain & inflammation (below)

Is anyone gonna try PEA? Let me know.

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