or, the biggest mouse study that’s ever been done (Hu, Speakman, et al., 2019)
Background rant: 20 years ago I thought I had a firm understanding of CIM. 10 years ago things got a little dicey here and there. Since then, the goalposts have been shifted so far and so frequently it’s a mess… we’ve come a long way from Atkins (for better or worse)
That said, regardless of where the goalposts were set, everyone should bookmark this study. They varied every macronutrient in nearly every possible way and took a variety of metabolic assessments (insulin sensitivity, body weight, food intake, etc.).
So whether or not their study tested the CIM to which you subscribe, there is still a ton of information here. My comments are mainly on CIM here lol
Speakman’s CIM is broken down into 5 somewhat overlapping parts.
- Increased dietary carbs increases fasting insulin which decreases fasting glucose
-In the context of any CIM, the postprandial state seems more relevant here; as in, ‘carbs increase insulin which reduces glucose and you get fat storage from the insulin and hangry from the hypo.’
These pork rinds are the bomb 🙂
2. Carbs and insulin induce de novo lipogenesis which makes you fat
-My only qualms here are: DNL is quantitatively more of a liver thing, and anyway, most of the fat that gets stored came straight from the diet, not DNL.
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