Melanocortin 4 Receptor

BREAKING: new MC4R agonist extremely effective in rare genetic obesity disorders. Probably others, too.

[Patron link]

Setmelanotide… (Clement et al., 2020)

Patients with hypoactive polymorphisms in the leptin receptor or POMC, fairly good results: many achieved 10% weight loss by year 1 and this was associated with significant declines in hunger scores.

remember Contrave?

These things are all tied together: leptin -> POMC -> aMSH -> MC4R -> reduction in appetite, increased energy expenditure. And I suspect improved signaling will be effective for many people with obesity… not that all types of obesity share a single cause, but this pathway seems to regulate a lot in this lane. In other words, it could be a common underlying pathway in many types of obesity.

For the rest of this article and more (or for the comparison chart at the very least), head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks 🙂

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Start your OWN Patreon campaign!

These pork rinds are the bomb. Seriously! And if you like spicy

Get some dark chocolate, too 

calories proper

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