hypothalamic leptin and insulin signaling

-regulation of body fat-

In healthy individuals, hypothalamic leptin and insulin signaling results in reduced appetite, increase satiety, and remove some of the brakes on energy expenditure.

It happens in the fed state and is shut down by fasting and stress.

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The problems come when these pathways exhibit inappropriate silencing, whether that’s due to some sort of resistance, failure of ligand to reach receptor, etc….

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Get some dark chocolate, too 

calories proper

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