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What’s more anti-cancer than ‘shrooms and isothiocyanates?
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Caffeine, large meals, and bright light in the evening induce circadian misalignment. That’s why these are better suited earlier in the day.
Caffeine reduces sleep pressure (which is supposed to start low in the morning and peak shortly after sunset) and delays melatonin onset (Burke et al., 2015). After dinner, make it a decaf or just pass.
Caffeine is an adenosine antagonist, and the accumulation of adenosine in the brain throughout the day is thought to be a chemical mediator of sleep pressure. Caffeine also delays and reduces melatonin, which increases your sleep needs, or at least time in bed/darkness.