Seed oils.

You asked for it. I’ve written about linoleic acid many times going back about a decade, long before the “seed oil” fiasco. 

[Patreon link]

Eg, Molested fats, and inflammatory, trans, or linoleate.

Also, of relevance: Marijuana (see below)

Older theories were that it induced a pro-inflammatory environment (or anti-anti-inflammatory), but one of my main conclusions was where it was found. What foods?

As a percentage of what’s actually consumed providing the bulk linoleic acid, it’s snacks, donuts,,, empty calories. So was it the inflammatory or trans fat aspect that causes metabolic problems, or is it confounded? 

Adiposink revisited?

More fapping fat-trapping? Or the all new pull model of obesity?

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Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

This mouse-alcohol-energy balance study is breaking the internet.

EBM & CIM crowd came out in droves. Everyone’s an expert on energy balance now :/

[Patreon link]

More energy in, alcohol spilling everywhere, where’s the CO2, and more!

Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Canagliflozin, semaglutide, and tirzepatide OH MY

New players (from oldest to newest). All work. Now it comes down to a cost:benefit analysis.

[Patron link]

Not “costs” as in risks or side effects, and mechanisms aside, but literal price. In other words, people who haven’t reached their goal body fat with keto & resistance training and have other options available 🙂

Canagliflozin is a SGLT-2 inhibitor, so you pee out glucose (kinda mimics a low carb diet, minimally, but has beneficial metabolic effects).

Next up: semaglutide, tirzepatide, and a cost:benefit analysis.

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Homemade Healthy Hot Mustard. Recipe.

Let’s just get the worst part out of the way first: mayo works great as a base and for texture, but there are other options.

 

Start with about a cup.

I like it chonky, so that’s how I chop the ingredients. If you like it smooth (like real McDonalds Hot Mustard sauce), dice things up smaller.

Cut up about half a medium sized tomato, 2-3 snips from the end of a bunch of scallions, half of a medium sized red onion, 3-5 garlic cloves (depending on preference), and stir ‘em all up in the mayo.

Add about half a teaspoon of your favorite pepper (I like fresh cracked [pepper grinder link here] mixed peppercorns or Grains of Paradise #biohack), ½ tbsp Coleman’s mustard powder (or more), thickener of choice (¼ tsp guar gum, a scoop of collagen or protein powder… you just need to soak up some of the liquids, really), 1/2 tsp potassium bicarbonate (to boost potassium intake, this is a good vessel for it) then spritz it with vinegar to activate. 

If you wanna cheat or make it more like the real thing, add a little pre-made hot salsa, hot mustard sauce, ketchup, whatever. If it’s too spicy, add more mayo. If it’s not spicy enough, figure it out!

Don’t hate me for this, but if you don’t want a calorie bomb and don’t mind frankenfoods, Walden Farms Amazin Mayo (which is nothing at all like real mayo) works well. Take about a whole jar of that into a stirring bowl.

Next up: keto McNuggets! …don’t get too excited, it’s just chicken chopped into nugget-sized bites, soaked in egg (or egg whites or milk, if PSMF or watching calories), then coated in either coconut flour or ground up pork rinds, according to preference/availability. Add some grated parmesan cheese if you want extra flavor and crispiness and don’t mind the calories. Baked in the oven, not fried in seed oils. You can add spices to the dry mix, but I use the hot mustard sauce to carry the weight here. GET UR PROTEINZZZ in a tasty way 🙂

Yeah, they look weird, not like real McNuggets, but waay healthier…..

Other recipe posts: 

The Spanakopita Experience

Dark chocolate. Can’t find the link at the moment, but it was basically cocoa powder, coconut oil, cocoa butter, sweeteners of choice, some unflavored protein powder for bulk, and maybe some salt, etc., iirc 🙂

That’s all for now!

Hey, check out my Patreon! Five bucks a month for access to all articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks 🙂

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

B&M, Bimagrumab and Miragrebon. Get your grubz on.

Bimagrumab: an elusive potential inhibitor of myostatin (the muscle blocker)

[Patron link]

Miragrebon: a beta-3 agonist, fueler of BAT thermogenesis

Tl;dr: both work. In addition to tirzepatide (or its subordinate, semaglutide), exercise in a [poly]pill may have arrived…… including UPF-free #eTRF if you are so inclined or striving for #Optimal™ jk 🙂 

Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity: A Phase 2 Randomized Clinical Trial (Heymsfeld et al., 2021)

Tl;dr: we weren’t wrong about myostatin, we just didn’t have the right tools to influence it. Now, we do.

Next time someone says you can’t gain muscle and lose fat at the same time, here’s another example proving them wrrrongo (pronounced with a rolling “r”):

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Tirzepa-what now??

And an old school tinkering “biohack” (if you can call it that; based on speculation, etc) (see below)

[Patron link]

Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes (Frias et al., 2021)

I shoulda saved “what a time to be alive!” for this post. You thought semaglutide was the greatest progress in managing obesity, right? Say hello to tirzepatide.

Both of these are once weekly subcutaneous injections. Semaglutide is available as a significantly cheaper generic; tirzepatide not yet (to my knowledge).

Weird-looking molecule,,, I bet it tickles more than one receptor…

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

#eTRF 2022

Yo! How you gonna design a weight loss study comparing two interventions but initiate the most rigorous ISOCALORIC reinforcements – regular counseling, phone calls, emails, etc., etc., to all but ensure no difference in weight loss? Yes, because CICO (don’t @ me).

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Early Time-Restricted Feeding for the Prevention of ...

And please don’t forget all the recent studies on #eTRF. Eg, Randomized controlled trial for time-restricted eating in healthy volunteers without obesity (Xie et al., 2022). #eTRF vs. skipping breakfast, #eTRF came out on top.

The new one is calorie restricted (both arms): TRF vs. non-TRF.

Early time-restricted feeding: health benefits - LCHFlove.com

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Death cycles of bodybuilders

RIP Cedric McMillan (2017-2022, age 44)

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Disclaimer: this is interwebz resurch; neither RCTs nor my wheelhouse, really. It could all be lies. This opinion piece is not restricted to dead athletes or bodybuilders, but also a commentary on performance enhancing drugs (PEDs) in general. It’s a complicated topic.

Stay tuned at the end for notable exceptions, black swans. It’s clearly not all dose and/or duration.

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Think of DHA like ball bearings

Excitement, glamour, and wild speculation ahead! Jk

[Patron link]

Suggested pre-reading: Vegetable oil fatty acids are not essential (P<0.05) (includes disclaimers)

In brief, the recommendations for essential fatty acids (EFAs) are based on animal models, some medium-quality evidence, and wishy washy endpoints. Eg, at what point does dermatitis become clinically severe enough to deem EFA deficiency, and can this be replicated in a double blind randomized controlled crossover trial? What are the control groups?

DHA numbers.svg

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Transgender in sports

TRIGGER WARNING

No offense intended. I don’t care much for woke culture. This isn’t about that. The memes are kinda funny tho… 

[Patron link]

Is this blog post cherry picking? Not intentionally, but there aren’t any double blind crossover RCTs on this.

We have competition results, what makes the news (highly suspect), social commentary, etc., etc.

This is what I was taught:

Simple, right?

There are many examples of transgender females dominating in men’s divisions but not of transgender males dominating in female’s divisions…

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper