They look identical to EEG studies on alcohol. When they work (not for everyone), they knock you out.
Not help you sleep.
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Check it out: Intraperitoneal administration of nesfatin?1 stimulates glucagon?like peptide?1 secretion in fasted mice (Tagawa et al., 2022)
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Exhibit A. Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing (Meier et al., 2022)
PC1/3 is involved in the activation and function of certain proteins.
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What do you think would happen if people were put on different diets under strictly controlled conditions, 16.5 vs 3.1 g seed oils/1000 kcal per day. Ad lib.
ABLC (animal-based low carb) vs. PBLF (plant-based low fat) (Hall et al., 2020)
SPIN DOCTORS STRIKE
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Context: I’ve been a follower of and advocate for low carb diets for over 20 years. For many reasons. But this new gen of ketards is setting us back decades.
First story is about the majestic GLP-1Ra (eg, semaglutide and tirzepatide). They act in the brain to suppress appetite very effectively. People report an inability to “clean their plates” like they used to. They eat less and lose fat. Clear victory for…..
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Older theories were that it induced a pro-inflammatory environment (or anti-anti-inflammatory), but one of my main conclusions was where it was found. What foods?
As a percentage of what’s actually consumed providing the bulk linoleic acid, it’s snacks, donuts,,, empty calories. So was it the inflammatory or trans fat aspect that causes metabolic problems, or is it confounded?
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Not “costs” as in risks or side effects, and mechanisms aside, but literal price. In other words, people who haven’t reached their goal body fat with keto & resistance training and have other options available 🙂
Canagliflozin is a SGLT-2 inhibitor, so you pee out glucose (kinda mimics a low carb diet, minimally, but has beneficial metabolic effects).
Next up: semaglutide, tirzepatide, and a cost:benefit analysis.
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Let’s just get the worst part out of the way first: mayo works great as a base and for texture, but there are other options.
Start with about a cup.
I like it chonky, so that’s how I chop the ingredients. If you like it smooth (like real McDonalds Hot Mustard sauce), dice things up smaller.
Cut up about half a medium sized tomato, 2-3 snips from the end of a bunch of scallions, half of a medium sized red onion, 3-5 garlic cloves (depending on preference), and stir ‘em all up in the mayo.
Add about half a teaspoon of your favorite pepper (I like fresh cracked [pepper grinder link here] mixed peppercorns or Grains of Paradise#biohack), ½ tbsp Coleman’s mustard powder (or more), thickener of choice (¼ tsp guar gum, a scoop of collagen or protein powder… you just need to soak up some of the liquids, really), 1/2 tsp potassium bicarbonate (to boost potassium intake, this is a good vessel for it) then spritz it with vinegar to activate.
If you wanna cheat or make it more like the real thing, add a little pre-made hot salsa, hot mustard sauce, ketchup, whatever. If it’s too spicy, add more mayo. If it’s not spicy enough, figure it out!
Don’t hate me for this, but if you don’t want a calorie bomb and don’t mind frankenfoods, Walden Farms Amazin Mayo (which is nothing at all like real mayo) works well. Take about a whole jar of that into a stirring bowl.
Next up: keto McNuggets! …don’t get too excited, it’s just chicken chopped into nugget-sized bites, soaked in egg (or egg whites or milk, if PSMF or watching calories), then coated in either coconut flour or ground up pork rinds, according to preference/availability. Add some grated parmesan cheese if you want extra flavor and crispiness and don’t mind the calories. Baked in the oven, not fried in seed oils. You can add spices to the dry mix, but I use the hot mustard sauce to carry the weight here. GET UR PROTEINZZZ in a tasty way 🙂
Yeah, they look weird, not like real McNuggets, but waay healthier…..
Dark chocolate. Can’t find the link at the moment, but it was basically cocoa powder, coconut oil, cocoa butter, sweeteners of choice, some unflavored protein powder for bulk, and maybe some salt, etc., iirc 🙂
That’s all for now!
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Miragrebon: a beta-3 agonist, fueler of BAT thermogenesis
Tl;dr: both work. In addition to tirzepatide (or its subordinate, semaglutide), exercise in a [poly]pill may have arrived…… including UPF-free #eTRF if you are so inclined or striving for #Optimal™ jk 🙂
Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity: A Phase 2 Randomized Clinical Trial (Heymsfeld et al., 2021)
Tl;dr: we weren’t wrong about myostatin, we just didn’t have the right tools to influence it. Now, we do.
Next time someone says you can’t gain muscle and lose fat at the same time, here’s another example proving them wrrrongo (pronounced with a rolling “r”):
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