Hey GLP-1 nerds, check out Nesfatin-1

(I’m including myself as a GLP-1 nerd)

[Patron link]

Check it out: Intraperitoneal administration of nesfatin?1 stimulates glucagon?like peptide?1 secretion in fasted mice (Tagawa et al., 2022

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

The All New “Uh-Oh CIM”

2 new mouse papers turning CIM upside down.

[Patron link]

Exhibit A. Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing (Meier et al., 2022)

PC1/3 is involved in the activation and function of certain proteins.

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

5x greater intake of seed oils. Place your bets!?

What do you think would happen if people were put on different diets under strictly controlled conditions, 16.5 vs 3.1 g seed oils/1000 kcal per day. Ad lib. 

[Patron link]

They’d start eating more and gain a ton of fat. Right? (See here for pictures of sample meals)

ABLC (animal-based low carb) vs. PBLF (plant-based low fat) (Hall et al., 2020)

SPIN DOCTORS STRIKE

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Rebranding GLP-1Ra & SGLT2i as “CIM”   O_o

Context: I’ve been a follower of and advocate for low carb diets for over 20 years. For many reasons. But this new gen of ketards is setting us back decades.

[Patreon link]

Rant warning.

First story is about the majestic GLP-1Ra (eg, semaglutide and tirzepatide). They act in the brain to suppress appetite very effectively. People report an inability to “clean their plates” like they used to. They eat less and lose fat. Clear victory for…..

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Seed oils.

You asked for it. I’ve written about linoleic acid many times going back about a decade, long before the “seed oil” fiasco. 

[Patreon link]

Eg, Molested fats, and inflammatory, trans, or linoleate.

Also, of relevance: Marijuana (see below)

Older theories were that it induced a pro-inflammatory environment (or anti-anti-inflammatory), but one of my main conclusions was where it was found. What foods?

As a percentage of what’s actually consumed providing the bulk linoleic acid, it’s snacks, donuts,,, empty calories. So was it the inflammatory or trans fat aspect that causes metabolic problems, or is it confounded? 

Adiposink revisited?

More fapping fat-trapping? Or the all new pull model of obesity?

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

This mouse-alcohol-energy balance study is breaking the internet.

EBM & CIM crowd came out in droves. Everyone’s an expert on energy balance now :/

[Patreon link]

More energy in, alcohol spilling everywhere, where’s the CO2, and more!

Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Canagliflozin, semaglutide, and tirzepatide OH MY

New players (from oldest to newest). All work. Now it comes down to a cost:benefit analysis.

[Patron link]

Not “costs” as in risks or side effects, and mechanisms aside, but literal price. In other words, people who haven’t reached their goal body fat with keto & resistance training and have other options available 🙂

Canagliflozin is a SGLT-2 inhibitor, so you pee out glucose (kinda mimics a low carb diet, minimally, but has beneficial metabolic effects).

Next up: semaglutide, tirzepatide, and a cost:benefit analysis.

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Homemade Healthy Hot Mustard. Recipe.

Let’s just get the worst part out of the way first: mayo works great as a base and for texture, but there are other options.

 

Start with about a cup.

I like it chonky, so that’s how I chop the ingredients. If you like it smooth (like real McDonalds Hot Mustard sauce), dice things up smaller.

Cut up about half a medium sized tomato, 2-3 snips from the end of a bunch of scallions, half of a medium sized red onion, 3-5 garlic cloves (depending on preference), and stir ‘em all up in the mayo.

Add about half a teaspoon of your favorite pepper (I like fresh cracked [pepper grinder link here] mixed peppercorns or Grains of Paradise #biohack), ½ tbsp Coleman’s mustard powder (or more), thickener of choice (¼ tsp guar gum, a scoop of collagen or protein powder… you just need to soak up some of the liquids, really), 1/2 tsp potassium bicarbonate (to boost potassium intake, this is a good vessel for it) then spritz it with vinegar to activate. 

If you wanna cheat or make it more like the real thing, add a little pre-made hot salsa, hot mustard sauce, ketchup, whatever. If it’s too spicy, add more mayo. If it’s not spicy enough, figure it out!

Don’t hate me for this, but if you don’t want a calorie bomb and don’t mind frankenfoods, Walden Farms Amazin Mayo (which is nothing at all like real mayo) works well. Take about a whole jar of that into a stirring bowl.

Next up: keto McNuggets! …don’t get too excited, it’s just chicken chopped into nugget-sized bites, soaked in egg (or egg whites or milk, if PSMF or watching calories), then coated in either coconut flour or ground up pork rinds, according to preference/availability. Add some grated parmesan cheese if you want extra flavor and crispiness and don’t mind the calories. Baked in the oven, not fried in seed oils. You can add spices to the dry mix, but I use the hot mustard sauce to carry the weight here. GET UR PROTEINZZZ in a tasty way 🙂

Yeah, they look weird, not like real McNuggets, but waay healthier…..

Other recipe posts: 

The Spanakopita Experience

Dark chocolate. Can’t find the link at the moment, but it was basically cocoa powder, coconut oil, cocoa butter, sweeteners of choice, some unflavored protein powder for bulk, and maybe some salt, etc., iirc 🙂

That’s all for now!

Hey, check out my Patreon! Five bucks a month for access to all articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks 🙂

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

B&M, Bimagrumab and Miragrebon. Get your grubz on.

Bimagrumab: an elusive potential inhibitor of myostatin (the muscle blocker)

[Patron link]

Miragrebon: a beta-3 agonist, fueler of BAT thermogenesis

Tl;dr: both work. In addition to tirzepatide (or its subordinate, semaglutide), exercise in a [poly]pill may have arrived…… including UPF-free #eTRF if you are so inclined or striving for #Optimal™ jk 🙂 

Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity: A Phase 2 Randomized Clinical Trial (Heymsfeld et al., 2021)

Tl;dr: we weren’t wrong about myostatin, we just didn’t have the right tools to influence it. Now, we do.

Next time someone says you can’t gain muscle and lose fat at the same time, here’s another example proving them wrrrongo (pronounced with a rolling “r”):

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

Tirzepa-what now??

And an old school tinkering “biohack” (if you can call it that; based on speculation, etc) (see below)

[Patron link]

Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes (Frias et al., 2021)

I shoulda saved “what a time to be alive!” for this post. You thought semaglutide was the greatest progress in managing obesity, right? Say hello to tirzepatide.

Both of these are once weekly subcutaneous injections. Semaglutide is available as a significantly cheaper generic; tirzepatide not yet (to my knowledge).

Weird-looking molecule,,, I bet it tickles more than one receptor…

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks ?

For personalized health consulting services: drlagakos@gmail.com.

Affiliate links that probably don’t work anymore: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Keto-mojo.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper