Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome (Depner et al., 2018)
Why you need to be mindful of circadian rhythms Every. Single. Day.
I once heard a joke – “I wish going to the gym was like going to high school. Once you get your diploma / get fit, you never need to go back” (or something like that). Unfortnately, circadian rhythms also fall into this category.
This study examined a pretty extreme model of circadian misalignment. Basically, they took a bunch of measurements during a normal day & night, then allowed the subjects a brief nap during the afternoon the next day, kept them up all night, then took more measurements during daytime sleep and evening wakefulness.
Looking at the bottom graph should tell you all you need to know about the importance of daily circadian entrainment. While some circadian clocks can maintain a normal rhythm for a little while after a period of circadian misalignment, look how quickly melatonin increased during the daytime in circadian misalignment. This didn’t really bode well for sleep as it declined by almost a full hour…
If you’re interested in setting up consultations with me, reach out: firstname.lastname@example.org.
Affiliate links: Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. If you have no idea what I’m talking about, read this then this.
If you want the benefits of ‘shrooms but don’t like eating them, Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else.