Three stories about LIGHT
Carbon monoxide (CO): one of the nasty things in car emissions & cigarette smoke. Also, a byproduct of the ever-important heme. Heme, as you may recall, activates Rev-erb:
“Food for thought: an endogenous ligand of Rev-erb is heme (the iron-binding element in red blood cells). Heme is degraded into bilirubin. Elevated levels of bilirubin cause jaundice. A treatment of neonatal jaundice is exposure to blue light. Blue light is a major regulator of circadian rhythms and Rev-erb is an executive-level player in this game. The primary mechanisms of blue light appear unrelated in these two models (melanopsin activation vs. bilirubin photoisomerization), but seem intertwined, because heme activates Rev-erb. Cool.”
Science: Reciprocal regulation of carbon monoxide and the circadian clock (Klemz et al., 2016)
Tl;dr: heme degradation occurs on a circadian cycle and produces CO. CO prevents Clock/Bmal1 from binding to DNA. Inhibiting this process throws off numerous other circadian rhythms in the liver.
Science: Gamma frequency entrainment attenuates amyloid load and modifies microglia (Iaccarino et al., 2016)
Tl;dr: mice exposed to LED light flickering 40x per second for one hour showed reduced amyloid in their brain over the next 12 hours.
LIGHT IS A FUCKING DRUG
Interestingly, 40x worked, but not constant light, nor 20 or 80. The frequency of brain gamma waves (25-80 Hz) may have something to do with it. The researchers theorized that disrupted gamma waves contribute to amyloid build-up, and flickering light within this frequency restores them. This re-invigorates microglia to gobble up amyloid plaques. Cool.
My only advice: if you’re gonna do it, do it in the morning with breakfast.
— Joshua Matettore (@joshfattore) December 14, 2016
Interesting point, Joshua. Various brain waves seem to be in the range of screen refresh rates… I don’t know, but I’m keeping my eye on this.
“The scientists discovered that the men who received active light treatment saw their testosterone levels increase and their sexual satisfaction improve.”
Science: Light therapy as a treatment for sexual dysfunction; focus on testosterone levels (Koukouna et al., 2016)
Tl;dr: morning sex with the lights on (there’s your fasted exercise LOL). Then breakfast.