Interleukin-1 beta: produced by activated M1 macrophages, classical fever-inducing cytokine, mediates cellular inflammation, and induces COX-2 (target of NSAIDs). Also involved in autoimmunity. You don’t want none of it but you certainly don’t want a lot of it.
This is a very specific effect: 1) many structurally similar compounds don’t block NLRP3; and 2) beta-hydroxybutyrate doesn’t block activation of other inflammasomes.
“In vivo, BHB or a ketogenic diet attenuates caspase-1 activation and IL-1b secretion in mouse models of NLRP3-mediated diseases such as Muckle-Wells syndrome, familial cold autoinflammatory syndrome and urate crystal-induced peritonitis. Our findings suggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of the NLRP3 inflammasome.”
Activation of the NLRP3 inflammasome is responsible for IL-1b secretion by activated macrophages.
If you have gout, certain autoimmune conditions, or maybe even Alzheimer’s, this may be a viable #context for ketone supps. The authors used 1,3-butanediol diesters:
^not commercially available yet, but mustn’t taste too bad because the mice actually ate it…
Another downside to chronically elevated IL-1b is type 2 diabetes. This study showed that hyperglycemia induced NLRP3 and IL-1b secretion which enhanced insulin secretion and glucose uptake into macrophages, which caused more pro-inflammatory effects. A vicious feed-forward cycle.
“Postprandial inflammation might be limited by normalization of glycemia, since it was prevented by inhibition of the sodium-glucose cotransporter SGLT2.”
Eat during the day, SLEEP at night. Sunlight. No junk food. Exercising after meals can be an effective band-aid because contracting muscles take up glucose independently from insulin, so it works even in insulin resistance.
If you like what I do and want to support it, become a Patron!! Full access for a five bucks a month and there are many other options. It’s ad-free and you can cancel if it sucks ????
Also, I’m open to suggestions, so please don’t hesitate to leave a comment or contact me directly at firstname.lastname@example.org.
UPDATED Affiliate links: still looking for a pair of hot blue blockers? Carbonshade is offering 15% off with the coupon code LAGAKOS and Spectra479 is offering 15% off HERE.
If you have no idea what I’m talking about, read this then this.
If you want the benefits of ‘shrooms but don’t like eating them, Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else.