Ketones inhibit lipolysis

Petro just posted a brief article about acipimox & the insulin hypothesis.  Similar to insulin’s forte, acipimox inhibits lipolysis.  This leads to expansion of adipose tissue, and eventually, weight gain.

Acipimox acts on the same receptor as niacin and ketones, GPR109a.  That is, all three of those agents inhibit lipolysis.  We’ve discussed some of the implications of this on fuel partitioning HERE.

 

ketone-supp-physiology

 

In brief, plasma lactate reflects muscle glycogen use.  During activity, you usually burn a mix of glycogen and fatty acids; more of the former with higher intensity activity (unless theoretically if you’re ketoadapted).  By inhibiting lipolysis with niacin, acipimox, or beta-hydroxybutyrate, the body is forced to rely more heavily on glycogen and this is reflected in higher plasma lactate.

 




 

Theoretically, by forcing the body into this higher intensity fuel usage, this could be a mild performance booster and might even explain the 2% advantage seen in the Cox study on ketone supps.  Probably won’t work with acipimox because it’s not a fuel; at least ketone supps are providing kcals.  Niacin: maybe, but for different reasons.

 

However, caution is warranted when taking ketone supps out of the #context of exercise.  Similar to mice given acipimox literally in the drinking water, ketone supps may promote an environment supporting expansion of adipose tissue by inhibiting lipolysis via GPR109a.

Also, ketone supps are sort-of-like empty calories; when you could be burning body fat (or glycogen), you’re displacing it with an exogenous fuel source.

 




 

So basically my advice remains unchanged: if that 2% performance advantage will benefit you, go for it.  Also potentially useful for mild cognitive impairment.  Not sure if Regular Joe’s should make ketone supps an everyday thing, though.

#context

 

 

More on ketone supps HERE.

 

I think the whole “ketones inhibit lipolysis” mechanism may have evolved *specifically* to prevent ketones from getting too high during starvation.  You’d be losing a lot of energy in the form of ketones via urinary excretion, ramping up renal gluconeogenesis, and wasting a lot of glutamine.

If you like what I do and want to support it, head over to Patreon! Five bucks a month for full access. It’s ad-free and you can cancel if it sucks 🙂

Also, I’m open to suggestions so feel free to leave a comment or email me directly at drlagakos@gmail.com.

Affiliate discounts: if you’re still looking for a pair of hot blue blockers, Carbonshade is offering 15% off with the coupon code LAGAKOS and Spectra479 is offering 15% off HERETrueDark is running a pretty big sale HEREIf you have no idea what I’m talking about, read this then this.

20% off some delish stocks and broths from Kettle and Fire HERE

If you want the benefits of  ‘shrooms but don’t like eating them, Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. (I recommend Lion’s Mane for the brain and Reishi for everything else).

calories proper

 

Become a Patron!

 

 

Save

Save

Save

Save

Save

Save

Save

Save

Save

Save

Save

Be Sociable, Share!
Share