You wanna burn fat? ATGL (Adipocyte Triacylglycerol Lipase) is your man. ATGL is responsible for breaking down fat, a necessary precondition for fat burning. Mice lacking ATGL accumulate tons of fat: 20x more in the heart, 10x more in testis, 3x more in skeletal muscles, 2x more in the GI tract, etc., etc. Not surprisingly, they’re overweight.
Part 1. The importance of the ability to un-store fat: appetite, body composition, and insulin.