Circadian rhythms and prostate cancer

Observations:

Incidence of prostate cancer is higher among pilots, flight attendants, and rotating shift workers than the general population (RR as high as 3.0 in some cases!).

Circadian rhythms of androgens is absent & clock genes are disrupted in prostate cancer; the latter of which is reversible with melatonin which also suppresses prostate cancer progression.

Interestingly, radiation treatment is significantly more effective before 5pm than after.  I don’t know why this is; could be a spurious correlation.  Or not.

 

 

Circadian rhythmicity and the influence of clock genes on prostate cancer (Kiss and Ghosh, 2016)

 

central-pacemaker

 

Two key players are the circadian proteins Per1 and Per2. They’re supposed to exhibit diurnal fluctuation but are suppressed in prostate cancer cells, and genetic overexpression inhibits tumor progression. 

 




 

And similar to Bmal2 SNPs and breast cancer progresssion, Bmal and Period SNPs are associated with prostate cancer incidence and severity.

 

melatonin

 

High levels of melatonin at night, which can be relatively easily achieved by avoiding artificial light and rocking hot blue blockers, are associated with lower incidence and severity of prostate cancer.

 




 

In rodent models of prostate cancer, administration of melatonin suppresses tumorigenesis.  Importantly, this is only seen with properly timed doses and not chronic infusions (ie, physiological melatonin exposure).  Circadian rhythms are clearly of great import.  Even specific dose-timing of anti-cancer drugs shows superior efficacy and lower toxicity over chronic infusions.

 

androgen

 

I’m not crazy. Light and food during the day, dark and sleep at night.  This is just how it needs to be.  QED.

Entraining central and peripheral circadian clocks

For full access to all articles and much more (or if you just like what I do and want to support it), become a Patron! Five bucks a month and there are many other options. It’s ad-free and you can cancel if it sucks 🙂

Also, I’m open to suggestions, so please don’t hesitate to leave a comment or contact me directly at drlagakos@gmail.com.

UPDATED Affiliate links: still looking for a pair of hot blue blockers? Carbonshade  is offering 15% off with the coupon code LAGAKOS and Spectra479 is offering 15% off HERE.
If you have no idea what I’m talking about, read this then this.

20% off some delish stocks and broths from Kettle and Fire HERE

If you want the benefits of  ‘shrooms but don’t like eating them, Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

 

Become a Patron!

 

 

Save

Save

Save

Save

Save

Save

Be Sociable, Share!
Share