Tag Archives: cancer

Funded by Big ‘Shrooma

Reishi, the mushroom of longevity.

“The goal is to maintain or improve brain function and physical performance. And not get cancer.”

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‘Shrooms-every-day is part of my long-term anti-cancer plan. It’s not always a lot per serving, but I try to do the whole variety thing as much as possible, whatever’s available.

Maybe it’s one of those ice-age fairy tales fallacies, but cultures around the world have attributed a large number of health benefits to ‘shrooms for literally, thousands of years:

Ganoderma [reishi] has a very long history in East Asia as a medicinal mushroom dating back to the Chinese materia medica ‘Shen Nung Ben Cao Jing,’ written between 206 BC and 8 AD. It was considered a superior tonic for prolonging life, preventing aging, and boosting qi.”

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TRP activation indicates an assassination attempt

Whether it’s a noxious odor or burning sensation, TRP channels are there to let you know something’s up. They’re why we feel sting, burn, itch, etc., etc.

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TRPV1 lights up just as much if you bite into a burning hot food as it does a hot pepper. It responds to physical heat and capsaicin.

The infamous wasabi receptor, TRPV1:

TRPA1 in the lungs reduces respiration because it’s activated by poisonous gases… so you end up breathing in less of the poisonous gas. Actually, respiratory TRPA1 activation will make a sleeping mouse wake up and flee!

And yet for some reason, TRPs are anti-cancer in a wide variety of #contexts.

New insights into pharmacological tools to TR(i)P cancer up (Gautier et al., 2014)

If you’re exposed to a TRP activator and escape, cool, if not, you die (jk). Unless it’s a false assassin, in which case that smarty TRP will be downregulated.

I’m happy to have not participated in this study:

Oral irritation by mustard oil: self-desensitization and cross-desensitization with capsaicin (Simons et al., 2003)

Jab a mouse with a large enough dose of capsaicin, early enough in life, and they’re virtually permanently desensitized (Gamse et al., 1980). Under no circumstances should you do this.



TRPA1 is actually upregulated in lung cancer cells (Schaefer et al., 2013). It’s unknown why, but given the chemopreventive nature of TRPs and the ability to modulate them, might a spicy meal or 2 be prudent?

For the rest of this article (and much more) head over to Patreon! Five bucks a month for full access and there are many other options. It’s ad-free and you can cancel if it sucks 🙂

Also, I’m open to suggestions so feel free to leave a comment or email me directly at drlagakos@gmail.com.

Affiliate discounts: if you’re still looking for a pair of hot blue blockers, Carbonshade is offering 15% off with the coupon code LAGAKOS and Spectra479 is offering 15% off HERETrueDark is running a pretty big sale HEREIf you have no idea what I’m talking about, read this then this.

20% off some delish stocks and broths from Kettle and Fire HERE

If you want the benefits of  ‘shrooms but don’t like eating them, Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else.


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Breast Cancer Awareness Month

“LIGHT for thought”

There are some things you can control and many more you can’t (eg, circadian disruption, alcohol, BRCA, etc.). It’s impossible to know how much circadian arrhythmia contributes to cancer risk, but the epidemiology is strong and some of the mechanistic work makes sense. It has to do with LIGHT and melatonin.

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Tl;dr: a robust circadian rhythm and proper melatonin peak at night mitigate a lot of other factors. If there’s artificial light at night, then there’s no melatonin, and that’s like, SHIELDS ARE DOWN! And it doesn’t take a lot to shut ‘em down.

There’s also a dietary angle, but it’s borderline one of those things you can’t change (unless you try really really hard) (more on this below), or at least not nearly as fast as you can fix melatonin (see HERE).


In 1978, Cohen and colleagues made a few seminal observations (Cohen et al., 1978). In their words,

“(1) Pineal calcification is commonest in countries with high rates of breast cancer and lowest in areas with a low incidence; the incidences of pineal calcification and of breast cancer are moderate among the black population in the United States.

(2) Chlorpromazine raises serum-melatonin; there are reports that psychiatric patients taking chlorpromazine have a lower incidence of breast cancer.

(3) Although information is lacking on breast cancer, the pineal and melatonin may influence tumour induction and growth in experimental animals.

(4) The demonstration of a melatonin receptor in human ovary suggests a direct influence of this hormone on the ovarian function, and possibly oestrogen production.

(5) Impaired pineal secretion is believed to be an important factor triggering puberty (early menarche is a risk factor for breast cancer).”


The dark side of light at night: physiological, epidemiological, and ecological consequences (Navara and Nelson, 2007)



And further observations, for example, that urinary melatonin is prospectively inversely associated with breast cancer (Schernhammer et al., 2008) and total blindness is protective against breast cancer (Flynn-Evans et al., 2009). Total visual blindness is associated with a variety of other problems, but they’re less likely to succumb to artificial light at night-induced melatonin suppression.


For the rest of this article or if you just like what I do and want to support it, head over to Patreon! Three bucks a month for access to all articles and there are many other options. There is a limited number of spots left at the $3 level so sign up soon! You can cancel at any time.
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Discounts: still looking for some hot blue-blockers? Carbonshade and Spectra479 are offering 15% off with the coupon code LAGAKOS. And for some delicious organic broths/stocks, Kettle & Fire is 20% off HERE.

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Ketones, Cancer, and the NLRP3 Inflammasome

“Check ‘em all. Do the work. There’s no room for cherry-picking here.


A few years back, researchers discovered the pseudo-ketone beta-hydroxybutyrate suppressed the NLRP3 inflammasome (Youm et al., 2015). NLRP3 is notorious for aggravating gout symptoms, so it was like: “Yay! A potentially clinically relevant use for ketone supps!” (I think there might be other applications as well, but that’s for another blog post).

Ketones, NLRP3, and IL-1b

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It’s thought that NLRP3 is around during active flares, so gout sufferers would stay on their regular meds and take ketone supps as needed – this is important because from what I understand, gout flares really suck, some people get them frequently, and ketone supps aren’t covered by insurance [yet?].


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