Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans (Morris et al., 2015)
“Glucose tolerance is lower in the evening and at night than in the morning.”
THE FIRST FRIGGIN’ LINE! Come on fam, please stop arguing against this fact. A basic tenet of circadian biology is our preparedness for food intake in the morning. “Skipping breakfast” is not hormetic. It’s CICO and not in a good way. Metabolism is gimped at night, so you end up having to eat less so you’re double-restricted (no breakfast and less food at night).
The point of this study was two-fold, in my estimation: 1) determine the normal circadian influences on glucose tolerance; and 2) influence of circadian misalignment.
When comparing the glycemic response to identical meals ingested after an identical period of fasting, either at 8 AM (subjective morning or “breakfast”) or 8 PM (subjective evening or “dinner”): postprandial glucose was 17% higher (ie, lower glucose tolerance) in the biological evening (8:00 PM) than morning (8:00 AM; ie, a circadian phase effect).
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