Two-thirds of the time, it works half of the time 🙂
Yes, we all pretend to know the mechanism how ketones may improve cognition in MCI/Alzheimer’s, but we don’t. Nobody does.
-Preferred fuel? kinda meaningless
-Epigenetics? Idk. Of those, I’d say probably all contribute somehow.
Ketogenic Diet Retention and Feasibility Trial #KDRAFT (Taylor et al., 2017)
Study design: 3 months MCT-supplemented ketogenic diet: 70% fat, 20% protein, <10% carbs; then one month on their former diet.
They started with 15-20 grams MCT (~10% of total calories) and gradually increased to 40%.
Of the 15 participants, 5 dropped out; of the 10 remaining, 5 had diarrhea. The former was attributed to the ketogenic diet, the latter to MCTs. This 1/2 of 2/3 [or whatever] was actually their primary objective – IOW, is keto feasible in this population? Secondary objective, which would kinda only matter if the primary objective was affirmative, how does this impact cognition?
Results: 5 people achieved pretty high ketosis for most of the time. Lots of variability, though, which may be due to their “conservative evaluation of ketosis.” Ie, instead of just being non-reported, days that ketones weren’t reported were counted as zero O_o which, depending how frequently this happened, could’ve driven down the average.
This part is actually pretty interesting: nearly all participants, especially the most protocol-compliant ones, experienced significant cognitive improvements during the 3-month intervention that promptly declined after one month back on their prior diet.
For the rest of this article, including a deeper analysis of the data and my interpretation, head over to Patreon! Five bucks a month for full access and there are many other options. It’s ad-free and you can cancel if it sucks 🙂
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