The basic biology of endogenous insulin secretion makes sense, physiologically/geographically.
It slams the liver first, which sees more concentrated insulin than any other tissue. By the time insulin reaches the periphery, a lot has already been cleared and it’s been considerably diluted by peripheral blood.
This makes sense because liver does a lot of the heavy lifting wrt blood glucose control. The first phase insulin secretion and all that jazz.
Skeletal muscle (SkM) and adipose tissue (AT) see just enough to enhance glucose clearance and slow down lipolysis.
Enter: new insulin analogs.
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