The ketogenic diet inhibits mTOR but spares muscle. Wait, wut?
mTOR is a key mediator of skeletal muscle growth. Primarily via stimulating protein synthesis, although some researchers are even looking for ways to activate it to prevent atrophy (eg, Dyle et al., 2014) (eg, ursolic acid & tomatidine).
Role of skeletal muscle mTOR in mechanical load-induced growth (Goodman et al., 2011)
Signaling pathways mediating muscle mass in aging skeletal muscle: role of mTOR (Sandri et al., 2013)
Mechanisms regulating skeletal muscle growth and atrophy (Schiaffino et al., 2013)
mTOR is necessary for proper satelite cell activity and skeletal muscle regeneration (Zhang et al., 2015)
Dietary protein lights up mTOR — 0.6 g/kg lean mass increased it by 30% in this study, although as little as 10-20 grams did it here.
“Many of the health benefits of exercise are mediated by mTOR, not only within the working muscle, but also in distant tissues such as fat, liver, and brain” (Watson et al., 2014).
Affiliate discounts: if you’re still looking for a pair of hot blue blockers, Carbonshade is offering 15% off with the coupon code LAGAKOS and Spectra479 is offering 15% off HERE. If you have no idea what I’m talking about, read this then this.
20% off some delish stocks and broths from Kettle and Fire HERE.
If you want the benefits of ‘shrooms but don’t like eating them, Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS.
For the rest of this story, full access to all articles, and much more (or if you just like what I do and want to support it), head over to Patreon! It’s three bucks a month and there are many other options. Sign up soon because there are only a limited number of spots left at the $3 level. It’s ad-free and you and you can cancel if it sucks 🙂
Also, I’m open to suggestions, so please don’t hesitate to leave a comment or contact me directly at drlagakos@gmail.com.
