Part I. Ketones are made from fat in the liver. But dietary fat has a lot of places to go and people to see, so it rarely gets to the liver en masse to a degree great enough to stimulate ketosis. Not so much for medium chain triglycerides (MCTs). Upon entry (ingestion), MCTs go to the liver and are metabolized to ketones without passing GO or collecting $200… but is this sufficient to reap the benefits of a ketogenic diet?
Exhibit A. Weight-loss diet that includes consumption of medium-chain triacylglycerol oil leads to a greater rate of weight and fat mass loss than does olive oil (St-Onge and Bosarge, 2008)
Healthy people assigned to either ~21grams of either MCTs or olive oil (~12% of total calories on a hypocaloric 1650 kcal/d weight loss diet) for 16 weeks:
Since ketones weren’t reported in this study, we have no way of knowing if they were even involved, but these data look very similar to those found in Partsalaki’s obese children put on a low calorie vs. ketogenic diet (Partsalaki et al., 2012):
and Hussain’s type II diabetics on low calorie vs. ketogenic (Hussain et al., 2012):
Thus far, data from the St-Onge’s MCT study look similar to two ketogenic diet studies (Partsalaki & Hussain). But ketones weren’t reported in any of these studies, so it’s hard to know if they were involved.
Exhibit B. Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: Estimated potential contribution to brain energy metabolism (Courchesne-Loyer et al., 2012)
Brain needs glucose. Or ketones. Elderly brains use 10-15% less glucose than young brains, and Alzheimer brains use 20-25% less. Thus, ketones stand to provide great benefit.
Healthy young adults given ~30 grams MCTs (C8-12) for 4 weeks. Plasma ketones tripled. 3X. This isn’t a ketogenic diet or starvation, where ketones increase 5-10 fold, but a normal diet with added MCTs… a major difference between the two is insulin levels: they didn’t budge in this study because carb consumption remained intact. We’re trying to “cheat” the ketogenic diet, remember?
St-Onge’s MCT oil study used 21 grams of MCTs which was accompanied by profound weight loss. Courchesne-Loyer showed that 30 grams can induce a pretty healthy state of ketosis. Do you think St-Onge’s subjects were ketotic? I do, especially because they were losing weight.
From our furry little friends,
MCTs increase HSL (Liu et al., 2011) & NE (Liu et al., 2012) in adipose from mice fed relatively low doses of MCTs (~2% [w/w]). Norepinephrine has a curious relationship with keto’s anti-epileptic activity, as mice lacking NET (read: increased noradrenergic signalling) still benefit from keto (Martillotti et al., 2006)… However, NE ko mice don’t (?) (Szot et al., 2001).
My guess is that a diet supplemented with MCTs or coconut oil will not be superior to bona fide keto, but could be a very effective adjunct to enhance traditional low carb.
Why not? MCTs lack that certain umph, or chutzpah, associated with ketogenic dieting –
MCTs vs. regular CTs (from Bosch et al., 2011):
Yes, these MCT-fed mice were eating less despite burning just as much, so they gained less body fat, but it was nothing like Garbow’s ketogenic mice who were eating way more yet still weighed less (Garbow et al., 2011):
Man cannot live on MCTs alone… but he’d probably do pretty well on low carb plus MCTs.