Liver is evil but need not be punished. SFAs.

What to serve with a liquid lunch, and a recipe for chocolate.

It’s like a feed forward downward spiral.  If you don’t eat saturated fat & MCTs prior to imbibing, then liver intentionally makes more PUFAs for the alcohol-induced burning ROS to molest.  Liver is evil but need not be punished.  SFAs.

Brief background: (Kirpich et al., 2011 & 2013)

Researchers studying alcohol in rodents know where they’re going and like to get there fast.  70 drinks per day fast.  Granted, rats metabolize faster than humans so it’s likely a little less… but a little less than 70 is still a lot of sauce.


The intervention:  Corn oil vs. Medium Chain Triglycerides (MCTs).  FTR MCTs are saturated fat and are abundant in MCT oil (duh) and coconut oil.Kirpich diets

The bender lasted 10 weeks, and well, a 35% alcohol diet bodes poorly for just about everything.Leaving Las Vegas

Especially liver.  Except if you’re on a PUFAless diet rich in MCTs.Kirpich liver data

Intestinal inflammation, endotoxin, and subsequent 3-alarm liver fire:intestine TNF

LPS and liver TNF

They were all pair-fed, but alcohol-fed rats weighed less because alcohol induces its own burning, on top of everything else (maybe some MEOS too, but to a similar effect).BW data

ie, excess alcohol ingestion results in higher TEETrogdor

More burning = more ROS = more bad news

Saturated fat is less susceptible to oxidative stress than PUFAs.  Corn oil is PUFAs.

Increases in dietary saturated fat increased liver membrane resistance to oxidative stress…” by replacing PUFAs with SFAs.

It works with cocoa butter too (You et al., 2005):cocoa butter

The absence of corn oil or presence of cocoa butter and/or MCTs is protective against alcohol-induced liver damage.  VERY protective.

It’s like a weird [cruel] trick – I’m led to think all alcohol ingestion is bad unless on a chocolate & coconut PUFAless diet.  Don’t get any ideas; I meant unsweetened or very dark chocolateI say ‘very’ dark because it just doesn’t seem prudent to carb-load prior to bending (insulin, SCD, etc., etc.).


“Fatty acid profiling demonstrated that alcohol feeding dramatically increased hepatic unsaturated long chain faty acyl species, particularly linoleic acid and oleic acid, which was attenuated by dietary MCT” (Li et al., 2013).  Huh?

It’s like a feed forward downward spiral.  If you don’t eat saturated fat & MCTs prior to imbibing, then liver intentionally makes more PUFAs for the alcohol-induced burning ROS to molest.  Liver is evil but need not be punished.  SFAs.

RECIPE TIME!

It probably takes a while to comprehensively remodel liver FA saturation, but why not pre-game with homemade dark chocolate?

8 oz. unsweetened chocolate
2 tbsp (1 oz.) Coconut oil

Sweeten to taste with either:
Erythritol (virtually calorie-free, provides bulk, non-laxative, and anti-diabetic),
Stevia (anti-diabetic, antioxidant, & renal-protective),
or Sucralose.

Optional: heavy cream (similar saturated fat quantity as cocoa butter, but a little more like MCT oil [some shorter chains]).

Gently melt chocolate, stir in other ingredients, pour into cupcake molds, refrigerate, and ¡voila!  Optional: sprinkle some sea salt on top prior to refrigeration.

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